Acute Severe Ulcerative Colitis - Clinical and Translational Studies

Grant number: 1142945 | Funding period: 2018 - 2021

Completed

Abstract

One in five patients with severe ulcerative colitis, a condition resulting in damage to the large bowel, may require surgery to remove the bowel. This project aims to find out how best to avoid surgery using a drug called infliximab which targets the immune system to reduce bowel damage. This study also aims to find changes in the immune system that cause ulcerative colitis and identify which patients are more likely to avoid surgery with infliximab thereby minimising side effects and costs.

Related publications (4)

Algorithms to facilitate shared decision-making for the management of mild-to-moderate ulcerative colitis

B Jackson, P De Cruz

2018-11-02

Introduction: Nonadherence has been a key barrier to the efficacy of medical treatments in ulcerative colitis (UC). Engaging patie..

Risk stratifying in real life

P De Cruz

2018-09-01

Examining maintenance care following infliximab salvage therapy for acute severe ulcerative colitis

D Seah, MC Choy, A Gorelik, WR Connell, MP Sparrow, D Van Langenberg, G Hebbard, G Moore, P De Cruz

2018-01-01

Background and Aim: Data supporting the optimal maintenance drug therapy and strategy to monitor ongoing response following succes..

Salvage therapy for acute severe ulcerative colitis during pregnancy

M Raval, MC Choy, P De Cruz

2018-01-01

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with an age of onset that affects young people during the peak of ..

University of Melbourne Researchers

Peter-Phillip de Cruz

Peter Angus